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Structure of 2609-49-6
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Diethyl (4-nitrobenzyl)phosphonate features a para-nitro group that enhances electrophilic reactivity while maintaining bench-stable handling. This phosphonate integrates readily into C–P bond formation, enabling efficient synthesis of functionalized phosphonates under mild conditions.
Diethyl (4-nitrobenzyl)phosphonate serves as a versatile building block in synthetic organic chemistry, enabling the efficient construction of phosphonate-containing heterocycles and bioactive scaffolds. Its benzylic phosphonate functionality exhibits excellent stability under standard reaction conditions and tolerates a range of functional groups, facilitating downstream transformations such as alkylation, oxidation, and cross-coupling. The electron-withdrawing 4-nitrophenyl group enhances the acidity of the α-proton, promoting facile enolization for C–H functionalization. This compound is particularly valuable in the synthesis of phosphorylated analogs relevant to medicinal chemistry and agrochemical development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: