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Structure of 261952-02-7
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2-Methyl-3-(trifluoromethyl)benzonitrile features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability. The ortho-methyl substituent provides steric protection to the nitrile functionality, improving handling and shelf life. This compound serves as a valuable building block in medicinal chemistry for constructing bioactive scaffolds with improved lipophilicity and membrane permeability.
2-Methyl-3-(trifluoromethyl)benzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of biologically active heterocycles via electrophilic substitution and transition-metal-catalyzed coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the nitrile moiety offers direct functionalization potential. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: