Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Methyl 6-Bromonicotinate

  • CAS No. 26218-78-0

  • Cat. No. CS-W003208
  • Purity≥97%
  • MDL No.MFCD04972371

*For research and further manufacturing use only, not for direct human use.

Methyl 6-Bromonicotinate|CS-W003208

Structure of 26218-78-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 26218-78-0
  • Cat. No. CS-W003208
  • Purity ≥97%
  • MDL No. MFCD04972371
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) Methyl-6-bromonicotinate; Methyl 6-bromonicotinate
  • SMILES COC(C1=CN=C(Br)C=C1)=O

Description

Methyl 6-bromonicotinate features a brominated pyridine ring that enables direct functionalization in cross-coupling reactions. The ester group provides a handle for further derivatization, while the electron-deficient aromatic core enhances reactivity in transition-metal-catalyzed processes. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical candidates.

Application

Methyl 6-bromonicotinate serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of substituted pyridine scaffolds. The bromine substituent exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the ester group provides orthogonal functionality for further derivatization. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      6-Bromonicotinic acid|CS-W002864
      6311-35-9
    • ~99%
    • In-stock
      Methyl 6-Bromonicotinate|CS-W003208
      26218-78-0

    References

    • Wang, Cheng; Xie, Zhigang; Dekrafft, Kathryn E.; Lin, Wenbin Journal of the American Chemical Society, 2011 , vol. 133, # 34 p. 13445 - 13454
  • Route2

    References

    • ELI LILLY AND COMPANY Patent: WO2004/94382 A1, 2004 ; Location in patent: Page 17-18 ; WO 2004/094382 A1
  • Route3
    • In-stock
      6-Bromonicotinic acid|CS-W002864
      6311-35-9
    • null|null
      18107-18-1
    • ~89%
    • In-stock
      Methyl 6-Bromonicotinate|CS-W003208
      26218-78-0

    References

    • Ruggi, Albert; Berenguel Alonso, Miguel; Reinhoudt, David N.; Velders, Aldrik H. Chemical Communications, 2010 , vol. 46, # 36 p. 6726 - 6728

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6307
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Methyl 6-Bromonicotinate sigmaMethyl 6-Bromonicotinate manufacturerMethyl 6-Bromonicotinate priceMethyl 6-Bromonicotinate structureMethyl 6-Bromonicotinate SDSbuy Methyl 6-BromonicotinateMethyl 6-Bromonicotinate supplierMethyl 6-Bromonicotinate usesMethyl 6-Bromonicotinate molecular weightprice of Methyl 6-BromonicotinateMethyl 6-Bromonicotinate chemical name formula of Methyl 6-Bromonicotinate
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label