CRBN ligand-394

Name: CRBN ligand-394
Brand: ChemScene
Availability: InStock
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CAS No. 2641512-77-6
Cat. No. CS-0928755
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 2641512-77-6

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Description

This piperidine-dione scaffold integrates a piperazinylphenyl moiety, delivering enhanced solubility and metabolic stability. The hydrochloride salt form ensures excellent crystallinity and handling convenience, enabling seamless incorporation into medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors under standard conditions.

Application

3-(4-(Piperazin-1-yl)phenyl)piperidine-2,6-dione hydrochloride serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide and C–H functionalization reactions. Its piperazine-aryl-piperidinedione architecture provides favorable solubility and metabolic stability, while the hydrochloride salt enhances bench stability and ease of handling. Functions effectively in parallel synthesis campaigns and offers orthogonal reactivity for late-stage derivatization.

General Information

CAS No. 2641512-77-6
Cat. No. CS-0928755
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₀ClN₃O₂
Molecular Weight 309.79
Synonym(s) None
SMILES Cl.O=C1NC(=O)C(C2=CC=C(C=C2)N3CCNCC3)CC1

Computational Chemistry Data

TPSA 61.44
LogP 1.0382
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Drug Discovery Cancer CDK

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CRBN ligand-394

CAS No. 2641512-77-6

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