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CS-W001157 4
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3-Bromo-2,6-dihydroxybenzoic acid

  • CAS No. 26792-49-4

  • Cat. No. CS-0135791
  • Molecule weight233.02
  • Purity≥95%
  • MDL No.MFCD03788827

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2,6-dihydroxybenzoic acid|CS-0135791

Structure of 26792-49-4

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General Information

  • CAS No. 26792-49-4
  • Cat. No. CS-0135791
  • Purity ≥95%
  • MDL No. MFCD03788827
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrO₄
  • Molecular Weight 233.02
  • Synonym(s) None
  • SMILES O=C(O)C1=C(O)C=CC(Br)=C1O

Description

3-Bromo-2,6-dihydroxybenzoic acid features a sterically hindered aromatic core with strategically positioned hydroxyl and bromine substituents, enabling selective functionalization in complex synthesis. The carboxylic acid group provides a robust anchor point for coupling reactions under standard conditions.

Application

3-Bromo-2,6-dihydroxybenzoic acid serves as a versatile building block for the synthesis of functionalized aromatic scaffolds, leveraging its orthogonal hydroxyl and carboxylic acid groups for selective derivatization. The bromo substituent enables palladium-catalyzed cross-coupling reactions, facilitating access to complex polyfunctional arenes. Its stability under standard bench conditions and compatibility with common protecting group strategies support efficient downstream transformations in medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1

    References

    • Doyle,F.P. et al. Journal of the Chemical Society, 1963 , p. 497 - 506

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   77.76
  • LogP   1.5585
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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