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CS-W001157 4
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tert-Butyl 4-acryloylpiperazine-1-carboxylate

  • CAS No. 270594-18-8

  • Cat. No. CS-0047370
  • Molecule weight240.30
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-acryloylpiperazine-1-carboxylate|CS-0047370

Structure of 270594-18-8

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General Information

  • CAS No. 270594-18-8
  • Cat. No. CS-0047370
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₀N₂O₃
  • Molecular Weight 240.30
  • Synonym(s) 1-Boc-4-acryloylpiperazine
  • SMILES O=C(N1CCN(C(C=C)=O)CC1)OC(C)(C)C

Description

tert-Butyl 4-acryloylpiperazine-1-carboxylate features a reactive acrylate handle tethered to a piperazine core, enabling efficient conjugation in bioconjugation and polymer functionalization. The tert-butyl ester group provides stability and ease of deprotection under mild acidic conditions. This compound integrates seamlessly into modular synthesis workflows for advanced materials and pharmaceutical intermediates.

Application

tert-Butyl 4-acryloylpiperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperazine-based scaffolds via conjugate addition or radical-mediated functionalization. Its acryloyl group facilitates Michael addition reactions under mild conditions, while the tert-butyl ester provides excellent bench stability and ease of deprotection. The molecule exhibits broad compatibility with diverse reaction partners, making it ideal for rapid library synthesis and late-stage derivatization in API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   49.85
  • LogP   1.2517
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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