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Structure of 28177-50-6
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2-Fluoro-6-iodophenol features a fluorine atom at the ortho position and an iodine substituent at the para position relative to the phenolic hydroxyl group. This electronic configuration enhances its utility in cross-coupling reactions, where the iodide serves as a reactive handle for palladium-catalyzed transformations. The molecule exhibits stability under standard bench conditions and facilitates efficient derivatization in synthetic workflows.
2-Fluoro-6-iodophenol serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl scaffolds under palladium catalysis. Its ortho-fluoro and iodo substituents provide complementary reactivity for sequential functionalization, with the iodide facilitating coupling and the fluorine offering potential for directed metallation or further substitution. The compound exhibits good bench stability and is readily purified by crystallization, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: