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CS-W001157 4
Total: USD 88.00

3-(Piperazin-1-yl)propanoic acid

  • CAS No. 27245-31-4

  • Cat. No. CS-0266536
  • Purity≥95%
  • MDL No.MFCD03161179

*For research and further manufacturing use only, not for direct human use.

3-(Piperazin-1-yl)propanoic acid|CS-0266536

Structure of 27245-31-4

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General Information

  • CAS No. 27245-31-4
  • Cat. No. CS-0266536
  • Purity ≥95%
  • MDL No. MFCD03161179
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄N₂O₂
  • Molecular Weight 158.20
  • Synonym(s) None
  • SMILES O=C(O)CCN1CCNCC1

Description

This piperazinylpropanoic acid derivative features a flexible aliphatic chain linking a protonatable piperazine ring to a carboxylic acid group. The molecule integrates a basic nitrogen-rich pharmacophore with a polar, ionizable terminus, enabling strong hydrogen bonding and enhanced solubility in aqueous media. Its structure supports efficient conjugation and salt formation for improved bioavailability.

Application

3-(Piperazin-1-yl)propanoic acid serves as a versatile bifunctional building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide conjugates. The piperazine moiety provides enhanced solubility and hydrogen-bonding capacity, while the carboxylic acid facilitates amide coupling and derivatization under standard conditions. Its bench-stable nature and compatibility with diverse reaction environments make it a practical choice for scaffold diversification in drug discovery workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   52.57
  • LogP   -0.6337
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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