(R)-1-(4-Chlorophenyl)ethanamine

Name: (R)-1-(4-Chlorophenyl)ethanamine
Brand: ChemScene
Availability: InStock
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CAS No. 27298-99-3
Cat. No. CS-0000291
Purity≥97%
MDL No.MFCD00671639

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1-(4-Chlorophenyl)ethanamine|CS-0000291

Structure of 27298-99-3

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Description

(R)-1-(4-Chlorophenyl)ethanamine is a chiral amine featuring a para-chlorinated phenyl group attached to a stereodefined ethylamine scaffold. This bench-stable compound serves as a key enantiomerically pure building block in asymmetric synthesis, particularly for pharmaceutical intermediates and ligands in catalytic systems. The aryl moiety enhances π-interaction potential, while the (R)-configuration enables precise stereocontrol in downstream transformations.

Application

(R)-1-(4-Chlorophenyl)ethanamine serves as a chiral building block for the synthesis of pharmaceutically relevant aryl ethylamine derivatives. Its well-defined stereochemistry enables stereoselective transformations in medicinal chemistry applications. The molecule exhibits good bench stability and functional group tolerance, facilitating straightforward incorporation into diverse synthetic routes, including amide coupling and reductive amination. It functions effectively as a precursor in the construction of bioactive heterocycles and API intermediates.

General Information

CAS No. 27298-99-3
Cat. No. CS-0000291
Purity ≥97%
MDL No. MFCD00671639
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀ClN
Molecular Weight 155.62
Synonym(s) (R)-4-Chloro-alpha-methylbenzylamine~ClophaR(tm
SMILES N[C@H](C)C1=CC=C(Cl)C=C1

Computational Chemistry Data

TPSA 26.02
LogP 2.3597
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS06,GHS09
Signal Word : Danger	UN#: 2810
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H315-H317-H318-H410
Precautionary Statements : P261-P273-P280

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-(4-Chlorophenyl)ethanamine

CAS No. 27298-99-3

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