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CS-W001157 4
Total: USD 88.00

1-(2-Trifluoromethylphenyl)ethylamine

  • CAS No. 273384-78-4

  • Cat. No. CS-0154087
  • Molecule weight189.18
  • Purity≥98%
  • MDL No.MFCD04038876

*For research and further manufacturing use only, not for direct human use.

1-(2-Trifluoromethylphenyl)ethylamine|CS-0154087

Structure of 273384-78-4

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General Information

  • CAS No. 273384-78-4
  • Cat. No. CS-0154087
  • Purity ≥98%
  • MDL No. MFCD04038876
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀F₃N
  • Molecular Weight 189.18
  • Synonym(s) Benzenemethanamine, a-methyl-2-(trifluoromethyl)-
  • SMILES CC(C1=CC=CC=C1C(F)(F)F)N

Description

1-(2-Trifluoromethylphenyl)ethylamine is a bench-stable, moisture-tolerant amine featuring a sterically hindered ethyl spacer linking the aromatic ring to the nitrogen. The para-trifluoromethyl group imparts strong electron-withdrawing character, enhancing reactivity in coupling processes. This structure enables efficient incorporation into bioactive scaffolds and functional polymers.

Application

1-(2-Trifluoromethylphenyl)ethylamine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the benzylic amine functionality facilitates straightforward derivatization via alkylation, acylation, or reductive amination. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.7251
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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