CRBN ligand-109

Name: CRBN ligand-109
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2758533-77-4
Cat. No. CS-0435062
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 2758533-77-4

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Description

CRBN ligand-109 is a potent, bench-stable small molecule that selectively engages the CRL4^CRBN E3 ubiquitin ligase complex. This compound integrates a unique heterocyclic scaffold designed to enhance target protein recruitment, enabling efficient degradation of disease-relevant proteins in cellular models.

Application

CRBN ligand-109 serves as a well-characterized molecular glue ligand for the CRL4^CRBN E3 ubiquitin ligase complex, enabling targeted protein degradation of specific substrates. It functions as a potent and selective recruiter of disease-relevant proteins to the ubiquitin-proteasome system, facilitating their degradation in cellular models. The compound exhibits favorable bench stability, moderate solubility, and compatibility with standard synthetic workflows, supporting its use in PROTAC development and target validation studies.

General Information

CAS No. 2758533-77-4
Cat. No. CS-0435062
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₈BrF₂NO₂
Molecular Weight 304.09
Synonym(s) None
SMILES O=C(C(C1=C(F)C=C(Br)C=C1F)CC2)NC2=O

Computational Chemistry Data

TPSA 46.17
LogP 2.2833
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Drug Discovery Cancer EGFR

Key Words

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CRBN ligand-109

CAS No. 2758533-77-4

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