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CS-W001157 4
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(2S,5R)-4-(tert-Butoxycarbonyl)-5-methylmorpholine-2-carboxylic acid

  • CAS No. 2761094-10-2

  • Cat. No. CS-0533136
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2S,5R)-4-(tert-Butoxycarbonyl)-5-methylmorpholine-2-carboxylic acid|CS-0533136

Structure of 2761094-10-2

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General Information

  • CAS No. 2761094-10-2
  • Cat. No. CS-0533136
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₅
  • Molecular Weight 245.27
  • Synonym(s) None
  • SMILES CC(C)(C)OC(N1C[C@H](OC[C@H]1C)C(O)=O)=O

Description

This chiral morpholine derivative features a tert-butoxycarbonyl-protected amine and a methyl-substituted ring, enabling direct incorporation into peptide synthesis. The (2S,5R) stereochemistry ensures high diastereoselectivity in coupling reactions, while the bench-stable Boc group simplifies purification and handling under standard conditions.

Application

(2S,5R)-4-(tert-Butoxycarbonyl)-5-methylmorpholine-2-carboxylic acid serves as a versatile chiral building block for the synthesis of bioactive heterocycles and peptide mimetics. Its stable tert-butyl carbamate group enables straightforward protection and deprotection, while the defined stereochemistry at C2 and C5 supports stereoselective transformations. The molecule functions effectively in amide coupling reactions and facilitates the construction of constrained morpholine-based scaffolds commonly found in medicinal chemistry campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   1.0954
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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