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Benzyl 3-formylpyrrolidine-1-carboxylate

  • CAS No. 276872-86-7

  • Cat. No. CS-0041769
  • Purity≥97%
  • MDL No.MFCD05861538
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Benzyl 3-formylpyrrolidine-1-carboxylate|CS-0041769

Structure of 276872-86-7

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Description

Benzyl 3-formylpyrrolidine-1-carboxylate features a pyrrolidine core with a formyl group at the 3-position and a benzyl ester handle, enabling direct incorporation into diverse synthetic sequences. The aldehyde functionality offers high reactivity for imine formation, while the bench-stable ester permits straightforward deprotection under standard conditions. This bifunctional scaffold supports rapid access to nitrogen-containing heterocycles and bioactive analogs in medicinal chemistry workflows.

Application

Benzyl 3-formylpyrrolidine-1-carboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to nitrogen-containing heterocycles and bioactive scaffolds. The aldehyde functionality facilitates reductive amination, Mannich reactions, and conjugate additions, while the benzyl ester offers convenient orthogonal deprotection under mild hydrogenolysis conditions. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis and medicinal chemistry applications.

General Information

  • CAS No. 276872-86-7
  • Cat. No. CS-0041769
  • Purity ≥97%
  • MDL No. MFCD05861538
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅NO₃
  • Molecular Weight 233.26
  • Synonym(s) 1-Benzyloxycarbonylpyrrolidine-3-Carboxaldehyde
  • SMILES O=C(N1CC(C=O)CC1)OCC2=CC=CC=C2

Computational Chemistry Data

  • TPSA   46.61
  • LogP   1.844
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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