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Structure of 461-84-7
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4-((Trifluoromethyl)thio)phenol features a trifluoromethylthio group appended to the para position of phenol, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration imparts strong lipophilicity and resistance to oxidative degradation, making it valuable for pharmaceutical intermediates and agrochemical synthesis. The compound exhibits favorable reactivity in nucleophilic substitution and transition-metal-catalyzed coupling processes under standard conditions.
4-((Trifluoromethyl)thio)phenol serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling the introduction of a strongly electron-withdrawing trifluoromethylthio group. Its stability under standard reaction conditions facilitates direct coupling reactions, including Suzuki-Miyaura and Ullmann-type transformations, and supports efficient functionalization in late-stage derivatization. The compound exhibits good bench stability and is compatible with common protecting group strategies.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: