tert-Butyl 4-(1H-pyrazol-4-yl)piperidine-1-carboxylate

Name: tert-Butyl 4-(1H-pyrazol-4-yl)piperidine-1-carboxylate
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CAS No. 278798-15-5
Cat. No. CS-0187675
Molecule weight251.32
Purity≥98%
MDL No.None

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tert-Butyl 4-(1H-pyrazol-4-yl)piperidine-1-carboxylate|CS-0187675

Structure of 278798-15-5

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General Information

CAS No. 278798-15-5
Cat. No. CS-0187675
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₁N₃O₂
Molecular Weight 251.32
Synonym(s) None
SMILES CC(C)(C)OC(=O)N1CCC(CC1)C2=CNN=C2

Description

tert-Butyl 4-(1H-pyrazol-4-yl)piperidine-1-carboxylate features a pyrazole-functionalized piperidine core with a bench-stable tert-butoxycarbonyl protecting group. This compound integrates readily into medicinal chemistry campaigns, enabling efficient access to bioactive heterocycles through straightforward deprotection. The electron-rich pyrazole moiety enhances target engagement in kinase and receptor modulation studies.

Application

tert-Butyl 4-(1H-pyrazol-4-yl)piperidine-1-carboxylate serves as a versatile building block for medicinal chemistry, enabling efficient access to pyrazole-containing piperidine scaffolds. The tert-butyl carbamate group provides excellent bench stability and facile removal under mild acidic conditions, while the 1H-pyrazol-4-yl moiety offers a robust hydrogen-bonding pharmacophore. It functions effectively in standard coupling reactions and supports diversification via late-stage functionalization, making it ideal for high-throughput synthesis of bioactive molecules.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 58.22
LogP 2.5242
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-(1H-pyrazol-4-yl)piperidine-1-carboxylate

CAS No. 278798-15-5

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