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Structure of 28165-60-8
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2,3-Dichloro-6-nitrophenol features a nitro group at the para position relative to the phenolic hydroxyl, conferring strong electron-withdrawing character. The adjacent dichloro substitution enhances electrophilicity and stabilizes reaction intermediates. This compound serves as a key building block in synthesizing advanced pharmaceutical intermediates and functionalized aromatic systems under standard bench conditions.
2,3-Dichloro-6-nitrophenol serves as a valuable building block in the synthesis of advanced heterocyclic systems and functionalized aromatic intermediates. Its reactivity is well-defined, enabling selective nucleophilic substitution at the C-6 position due to strong electron-withdrawing effects from the nitro group. The dichloro substitution pattern provides orthogonal handles for sequential coupling reactions, facilitating access to complex scaffolds under mild conditions. Bench-stable and readily purified by recrystallization, it functions effectively in standard cross-coupling and cyclization protocols used in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: