2-Chloro-3-fluoro-6-methyl-4-pyridinamine

Name: 2-Chloro-3-fluoro-6-methyl-4-pyridinamine
Brand: ChemScene
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CAS No. 2864417-86-5
Cat. No. CS-0638064
Purity≥95%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-3-fluoro-6-methyl-4-pyridinamine|CS-0638064

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General Information

CAS No. 2864417-86-5
Cat. No. CS-0638064
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆ClFN₂
Molecular Weight None
Synonym(s) None
SMILES NC1=C(F)C(Cl)=NC(C)=C1

Description

2-Chloro-3-fluoro-6-methyl-4-pyridinamine features a trifunctional pyridine core with orthogonal reactivity, enabling direct incorporation into diverse heterocyclic scaffolds. The electron-deficient ring facilitates nucleophilic substitution, while the methyl group provides a handle for further functionalization. This bench-stable intermediate demonstrates excellent compatibility in transition-metal-catalyzed coupling processes and is particularly suited for synthesizing bioactive nitrogen-containing architectures.

Application

2-Chloro-3-fluoro-6-methyl-4-pyridinamine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds relevant in medicinal chemistry. Its orthogonal halogen and amine functionalities facilitate sequential coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig transformations. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthetic workflows in API development.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 38.91
LogP 1.76472
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-Chloro-3-fluoro-6-methyl-4-pyridinamine

CAS No. 2864417-86-5

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