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CS-W001157 4
Total: USD 88.00

4-(2,4-Difluorophenoxy)aniline

  • CAS No. 286932-63-6

  • Cat. No. CS-0369873
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(2,4-Difluorophenoxy)aniline|CS-0369873

Structure of 286932-63-6

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General Information

  • CAS No. 286932-63-6
  • Cat. No. CS-0369873
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉F₂NO
  • Molecular Weight 221.20
  • Synonym(s) 4-(2,4-DIFLUOROPHENOXY)PHENYLAMINE
  • SMILES FC1=CC=C(C(F)=C1)OC2=CC=C(C=C2)N

Description

4-(2,4-Difluorophenoxy)aniline features a fluoro-substituted phenoxy linker that enhances electron-withdrawing character and metabolic stability. This aniline derivative integrates seamlessly into pharmaceutical scaffolds, offering improved binding affinity and solubility in polar solvents under standard conditions.

Application

4-(2,4-Difluorophenoxy)aniline serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling the construction of bioactive heterocycles via standard coupling reactions. Its dual functionality—phenolic ether and primary amine—supports orthogonal derivatization, while the electron-withdrawing fluorines enhance metabolic stability and modulate electronic properties. The compound exhibits good bench stability and is amenable to purification by chromatography or recrystallization, facilitating integration into multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H316-H319
Precautionary Statements : P264-P270-P280-P330-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   3.3393
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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