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Structure of 287730-14-7
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5,6-Dichloro-1H-benzimidazole-2-carboxylic acid features a rigid heteroaromatic core with two electron-withdrawing chlorine substituents flanking the carboxylic acid group. This configuration imparts enhanced stability and polarity, facilitating integration into bioactive scaffolds for medicinal chemistry campaigns. The compound serves as a key building block in the synthesis of kinase inhibitors and other targeted therapeutics.
5,6-Dichloro-1H-benzimidazole-2-carboxylic acid serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive scaffolds through established coupling and functionalization reactions. Its dual electron-withdrawing chloro groups enhance electrophilicity at the C2 position, facilitating nucleophilic substitution and palladium-catalyzed cross-coupling. The carboxylic acid moiety supports direct derivatization via amide formation or esterification, offering convenient access to analogs for structure-activity studies. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P261-P280-P304+P340
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Lot numbers can be found on the outside label of a product: