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CS-W001157 4
Total: USD 88.00

4-(4-(Trifluoromethoxy)phenoxy)piperidine

  • CAS No. 287952-67-4

  • Cat. No. CS-0051074
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(4-(Trifluoromethoxy)phenoxy)piperidine|CS-0051074

Structure of 287952-67-4

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General Information

  • CAS No. 287952-67-4
  • Cat. No. CS-0051074
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄F₃NO₂
  • Molecular Weight 261.24
  • Synonym(s) 4-[4-(Trifluoromethoxy)phenoxy]piperidine
  • SMILES FC(F)(F)OC1=CC=C(OC2CCNCC2)C=C1

Description

4-(4-(Trifluoromethoxy)phenoxy)piperidine features a trifluoromethoxy-substituted aromatic ring linked via an ether bond to a piperidine heterocycle. This combination imparts enhanced lipophilicity and metabolic stability, making the compound valuable for medicinal chemistry applications involving CNS-targeted small molecules.

Application

4-(4-(Trifluoromethoxy)phenoxy)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization protocols. Its trifluoromethoxy-substituted aryl ether moiety confers enhanced metabolic stability and lipophilicity, while the piperidine nitrogen facilitates salt formation and hydrogen bonding. The compound exhibits good bench stability and is compatible with common reaction conditions, simplifying purification and integration into lead optimization campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.49
  • LogP   2.716
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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