Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate

  • CAS No. 287953-54-2

  • Cat. No. CS-W022588
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate|CS-W022588

Structure of 287953-54-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 287953-54-2
  • Cat. No. CS-W022588
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₆ClNO₄S
  • Molecular Weight 317.79
  • Synonym(s) N-benzyloxycarbonyl-4-piperidine sulfonyl chloride
  • SMILES O=C(N1CCC(S(=O)(Cl)=O)CC1)OCC2=CC=CC=C2

Description

Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate features a reactive chlorosulfonyl group enabling direct sulfonation of nucleophiles. This bench-stable, moisture-tolerant reagent integrates seamlessly into synthetic sequences requiring sulfonyl transfer, offering high functional group compatibility and clean reaction profiles under standard conditions.

Application

Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate serves as a versatile synthetic intermediate for constructing piperidine-based scaffolds. The chlorosulfonyl group enables efficient derivatization via nucleophilic substitution, facilitating the installation of diverse amine functionalities. Its benzyl ester moiety offers stability and ease of removal under standard hydrogenolysis conditions. This reagent demonstrates robust functional group tolerance and is well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      633312-80-8
    • ~85%
    • In-stock
      Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate|CS-W022588
      287953-54-2

    References

    • WO2003/103669 A1, ; Page 44-45 ; WO 03/103669 A1
  • Route2

    References

    • EP1403255 A1, ; Page 90 ; EP 1403255 A1
  • Route3
    • null|null
      7782-50-5
    • In-stock
      Benzyl 4-(acetylthio)piperidine-1-carboxylate|CS-0463852
      146827-60-3
    • ~81%
    • In-stock
      Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate|CS-W022588
      287953-54-2

    References

    • WO2003/103669 A1, ; Page 44-45 ; WO 03/103669 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   63.68
  • LogP   2.3562
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 287953-54-2 sigma287953-54-2 manufacturer287953-54-2 price287953-54-2 structure287953-54-2 SDSbuy 287953-54-2287953-54-2 supplier287953-54-2 uses287953-54-2 molecular weightprice of 287953-54-2287953-54-2 chemical name formula of 287953-54-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label