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Structure of 288-99-3
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1,3,4-Oxadiazole is a heterocyclic scaffold prized for its metabolic stability and ability to form strong dipole-dipole interactions. This electron-deficient ring integrates readily into bioactive molecules, enhancing membrane permeability and target binding affinity in medicinal chemistry applications.
1,3,4-Oxadiazole serves as a robust bioisostere for esters and amides, offering enhanced metabolic stability and improved solubility in medicinal chemistry applications. Its inherent thermal and hydrolytic stability facilitates handling and purification, while enabling diverse functionalization through electrophilic substitution or transition-metal-catalyzed coupling reactions. This heterocycle functions as a key scaffold in the synthesis of pharmaceutical intermediates and agrochemicals, providing predictable reactivity in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Danger
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UN#: 1993
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Class : 4.1
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Packing Group : Ⅱ
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Hazard Statements : H225
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501
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Lot numbers can be found on the outside label of a product: