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Structure of 52838-39-8
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5-Methyl-1,3,4-oxadiazol-2-amine features a polar oxadiazole core with a methyl group at the 5-position and a primary amine at the 2-position. This configuration imparts enhanced solubility and hydrogen-bonding capacity, enabling efficient incorporation into bioactive scaffolds. The compound serves as a robust heterocyclic building block for medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.
5-Methyl-1,3,4-oxadiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through well-established functional group transformations. Its amine functionality facilitates derivatization via acylation, alkylation, and coupling reactions, while the oxadiazole ring imparts metabolic stability and favorable physicochemical properties. The methyl substituent enhances lipophilicity and can influence binding interactions. This compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for high-throughput synthesis and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: