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Structure of 291312-74-8
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5-Bromo-2-(trimethylsilyl)pyridine features a strategically positioned trimethylsilyl group that enhances stability and facilitates orthogonal functionalization. The bromine at the 5-position enables palladium-catalyzed cross-coupling reactions under mild conditions. This pyridine derivative serves as a robust building block for synthesizing complex heterocyclic architectures in medicinal chemistry and materials science.
5-Bromo-2-(trimethylsilyl)pyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient late-stage functionalization of heterocyclic scaffolds. The bromine and silyl groups provide orthogonal reactivity: the bromide participates in palladium-catalyzed couplings (e.g., Suzuki, Stille), while the trimethylsilyl group offers protection and facilitates selective desilylation or further transformation. Bench-stable and compatible with standard synthetic workflows, it enables rapid diversification in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: