5-Chloro-1H-indol-7-amine

Name: 5-Chloro-1H-indol-7-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 292636-11-4
Cat. No. CS-0050545
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 292636-11-4

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Description

5-Chloro-1H-indol-7-amine features a chlorine substituent at the 5-position of the indole core, enhancing electron deficiency and directing electrophilic substitution. This bench-stable amine integrates readily into pharmaceutical scaffolds, offering high reactivity for C–N coupling reactions and serving as a key intermediate in bioactive molecule synthesis.

Application

5-Chloro-1H-indol-7-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its ortho-amino functionality facilitates efficient derivatization, while the chlorine substituent provides a handle for further functionalization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

General Information

CAS No. 292636-11-4
Cat. No. CS-0050545
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇ClN₂
Molecular Weight 166.61
Synonym(s) 7-AMino-5-chloroindole
SMILES NC1=CC(Cl)=CC2=C1NC=C2

Computational Chemistry Data

TPSA 41.81
LogP 2.4035
H_Acceptors 1
H_Donors 2
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Key Words

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5-Chloro-1H-indol-7-amine

CAS No. 292636-11-4

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