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Structure of 2996-31-8
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2-Fluoro-4-iodo-1-nitrobenzene features a trifunctional aromatic core with strategically positioned fluorine, iodine, and nitro groups. This configuration enables direct incorporation into cross-coupling cascades and facilitates downstream derivatization via nucleophilic substitution or metal-catalyzed transformations. The electron-deficient aryl framework enhances reactivity in Pd-mediated processes, while the fluorine substituent provides metabolic stability and modulates electronic properties.
2-Fluoro-4-iodo-1-nitrobenzene serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of biaryl scaffolds via palladium-catalyzed reactions. The ortho-fluoro substituent facilitates directed ortho-metalation, while the iodo and nitro groups provide complementary handles for sequential functionalization. Its bench-stable nature and compatibility with standard coupling conditions make it ideal for synthesizing complex heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: