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Structure of 30129-20-5
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1-Bromo-4-(trifluoromethyl)cyclohexane features a bromine atom at C1 and a trifluoromethyl group at C4 of the cyclohexane ring, creating a sterically defined, electron-deficient platform. This configuration enables selective functionalization in synthetic sequences, particularly in cross-coupling reactions where the trifluoromethyl group enhances metabolic stability and lipophilicity. The compound exhibits robust bench stability under standard conditions and is compatible with a range of transition metal catalysts.
1-Bromo-4-(trifluoromethyl)cyclohexane serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of fluorinated cyclohexane scaffolds. Its bromine functionality facilitates palladium-catalyzed cross-coupling reactions, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H225-H315-H319
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P302+P352-P362+P364-P370+P378-P501
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Lot numbers can be found on the outside label of a product: