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CS-W001157 4
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Dimethoxy(methyl)(phenyl)silane

  • CAS No. 3027-21-2

  • Cat. No. CS-0150978
  • Molecule weight182.29
  • Purity≥98%
  • MDL No.MFCD00008343

*For research and further manufacturing use only, not for direct human use.

Dimethoxy(methyl)(phenyl)silane|CS-0150978

Structure of 3027-21-2

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General Information

  • CAS No. 3027-21-2
  • Cat. No. CS-0150978
  • Purity ≥98%
  • MDL No. MFCD00008343
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄O₂Si
  • Molecular Weight 182.29
  • Synonym(s) methylphenyldimethoxysilane
  • SMILES CO[Si](C)(C1=CC=CC=C1)OC

Description

Dimethoxy(methyl)(phenyl)silane features a phenyl group and methyl substituent on silicon, enabling controlled hydrolysis and condensation. This structure delivers enhanced stability during storage while facilitating efficient integration into hybrid organic-inorganic materials and surface modification applications.

Application

Dimethoxy(methyl)(phenyl)silane serves as a stable, bench-ready silylating agent enabling selective protection of alcohols and amines under mild conditions. Its methyl and phenyl groups provide favorable steric and electronic tuning, while the dimethoxy functionality facilitates clean hydrolysis. The reagent exhibits excellent functional group tolerance and simplifies purification in multi-step syntheses, making it well-suited for complex molecule assembly in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      67-56-1
    • null|null
      149-74-6
    • ~86%
    • In-stock
      Dimethoxy(methyl)(phenyl)silane|CS-0150978
      3027-21-2

    References

    • Reikhsfel'd, V. O.; Flerova, N. I.; Filippov, N. A.; Zaslavskaya, T. N. J. Gen. Chem. USSR (Engl. Transl.), 1980 , vol. 50, # 9 p. 2017 - 2022,1629 - 1633
  • Route2
    • null|null
      67-56-1
    • null|null
      766-08-5
    • ~83%
    • In-stock
      Dimethoxy(methyl)(phenyl)silane|CS-0150978
      3027-21-2

    References

    • Lorenz, Catrin; Schubert, Ulrich Chemische Berichte, 1995 , vol. 128, # 12 p. 1267 - 1270
  • Route3
    • null|null
      67-56-1
    • null|null
      130648-88-3
    • ~26%
    • In-stock
      Dimethoxy(methyl)(phenyl)silane|CS-0150978
      3027-21-2
    • null|null
      144890-43-7
    • null|null
      144889-92-9

    References

    • Chemistry of Heterocyclic Compounds, , vol. 33, # 2 p. 161 - 163

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   1.2584
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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