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Structure of 30319-05-2
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3-Bromo-2-methylthiophene is a bench-stable, electron-deficient heterocycle featuring a bromine substituent at the 3-position and a methyl group at the 2-position. This configuration enables direct coupling in cross-coupling reactions, delivering functionalized thiophene scaffolds with high regiocontrol. The molecule integrates readily into synthetic sequences requiring halogenated building blocks for C–C or C–heteroatom bond formation.
3-Bromo-2-methylthiophene serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions for the construction of biologically relevant thiophene derivatives. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl group enhances regioselectivity and electronic tuning. Bench-stable and readily purified by distillation, it functions effectively in iterative synthetic sequences and is well-suited for medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS02,GHS06
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Signal Word : Danger
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UN#: 1992
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Class : 3 (6.1)
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Packing Group : Ⅱ
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Hazard Statements : H226-H301-H311-H315-H319-H331-H335-H412
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Precautionary Statements : P210-P240-P241-P242-P243-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P370+P378
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Lot numbers can be found on the outside label of a product: