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CS-W001157 4
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2-(4-Bromopyridin-2-yl)acetonitrile

  • CAS No. 312325-73-8

  • Cat. No. CS-0134612
  • Purity≥98%
  • MDL No.MFCD09999985

*For research and further manufacturing use only, not for direct human use.

2-(4-Bromopyridin-2-yl)acetonitrile|CS-0134612

Structure of 312325-73-8

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General Information

  • CAS No. 312325-73-8
  • Cat. No. CS-0134612
  • Purity ≥98%
  • MDL No. MFCD09999985
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂
  • Molecular Weight 197.03
  • Synonym(s) 2-CyanoMethyl-4-broMopyridine
  • SMILES N#CCC1=NC=CC(Br)=C1

Description

2-(4-Bromopyridin-2-yl)acetonitrile features a brominated pyridine ring coupled to an acetonitrile group, enabling direct incorporation into Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. This bench-stable building block facilitates the synthesis of functionalized heterocycles in medicinal chemistry and materials science applications.

Application

2-(4-Bromopyridin-2-yl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromine and nitrile functionalities. The acetonitrile group enhances solubility and facilitates downstream transformations, while the pyridine ring provides a rigid scaffold for target-directed synthesis. Bench-stable and readily purified, it functions effectively in standard coupling protocols, including Suzuki-Miyaura and Buchwald-Hartwig reactions, supporting efficient access to complex heterocyclic architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.91018
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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