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CS-W001157 4
Total: USD 88.00

Bromo-PEG3-bromide

  • CAS No. 31255-26-2

  • Cat. No. CS-0114577
  • Purity≥96%
  • MDL No.MFCD18205853

*For research and further manufacturing use only, not for direct human use.

Bromo-PEG3-bromide|CS-0114577

Structure of 31255-26-2

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General Information

  • CAS No. 31255-26-2
  • Cat. No. CS-0114577
  • Purity ≥96%
  • MDL No. MFCD18205853
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆Br₂O₃
  • Molecular Weight 320.02
  • Synonym(s) None
  • SMILES BrCCOCCOCCOCCBr

Description

Bromo-PEG3-bromide is a bifunctional crosslinker featuring two reactive bromo groups separated by a three-ether-unit polyethylene glycol spacer. This structure enables efficient conjugation in aqueous or organic media, facilitating the attachment of biomolecules, polymers, or surface-bound ligands with controlled spacing and enhanced solubility.

Application

Bromo-PEG3-bromide serves as a versatile bifunctional linker for the synthesis of PEGylated compounds and functionalized polymers. Its terminal bromide groups enable efficient coupling reactions with amines, thiols, and nucleophilic heterocycles under standard conditions. The three-ethylene glycol unit provides enhanced solubility and stability in aqueous and organic media, facilitating purification and downstream applications in drug delivery and bioconjugation.

Synthesis

  • Route1
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • ~88%
    • In-stock
      Bromo-PEG3-bromide|CS-0114577
      31255-26-2

    References

    • Biron, Eric; Otis, Francois; Meillon, Jean-Christophe; Robitaille, Martin; Lamothe, Julie; Van Hove, Patrick; Cormier, Marie-Eve; Voyer, Normand Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1279 - 1290
  • Route2
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • null|null
      603-35-0
    • ~68%
    • In-stock
      Bromo-PEG3-bromide|CS-0114577
      31255-26-2
    • In-stock
      Triphenylphosphine oxide|CS-Z0018
      791-28-6

    References

    • Hurley, Christopher A.; Wong, John B.; Ho, Jimmy; Writer, Michele; Irvine, Scott A.; Lawrence, M. Jayne; Hart, Stephen L.; Tabor, Alethea B.; Hailes, Helen C. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 14 p. 2554 - 2559
  • Route3

    References

    • Breyholz, Hans-Joerg; Wagner, Stefan; Faust, Andreas; Riemann, Burkhard; Hoeltke, Carsten; Hermann, Sven; Schober, Otmar; Schaefers, Michael; Kopka, Klaus ChemMedChem, 2010 , vol. 5, # 5 p. 777 - 789

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   1.826
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   10

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