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CS-W001157 4
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2-Chloro-5-fluoropyridine

  • CAS No. 31301-51-6

  • Cat. No. CS-W009123
  • Purity≥98%
  • MDL No.MFCD03095332

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-fluoropyridine|CS-W009123

Structure of 31301-51-6

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General Information

  • CAS No. 31301-51-6
  • Cat. No. CS-W009123
  • Purity ≥98%
  • MDL No. MFCD03095332
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFN
  • Molecular Weight None
  • Synonym(s) Benzoic acid, 2-amino-3-(trifluoromethyl)-
  • SMILES FC1=CN=C(Cl)C=C1

Description

2-Chloro-5-fluoropyridine is a heterocyclic building block featuring complementary halogen substituents that enable selective cross-coupling reactions. The electron-deficient pyridine core supports palladium-catalyzed transformations, while the ortho-chloro and meta-fluoro groups offer distinct reactivity profiles for sequential functionalization. This molecule integrates readily into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

2-Chloro-5-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chloro and fluoro substituents facilitate sequential functionalization, while the pyridine core provides a stable, electron-deficient platform for heterocycle synthesis. Bench-stable and compatible with standard purification methods, it supports efficient access to complex scaffolds in API development.

Synthesis

  • Route1

    References

    • Garel, Laurent; Saint-Jalmes, Laurent Patent: US2007/276168 A1, 2007 ; Location in patent: Page/Page column 9 ;
  • Route2

    References

    • Yamada, Shigeyuki; Knochel, Paul Synthesis, 2010 , # 14 art. no. T09010SS, p. 2490 - 2494
  • Route3

    References

    • Organic Letters, , vol. 15, # 19 p. 5134 - 5137

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H226-H302-H315-H318-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.8741
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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