2,5-Difluoropyridine

Name: 2,5-Difluoropyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 84476-99-3
Cat. No. CS-W003160
Purity≥97%
MDL No.MFCD04114191

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 84476-99-3

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Description

2,5-Difluoropyridine serves as a key heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and modulated electron density. The strategically positioned fluorine atoms enable directed functionalization via cross-coupling reactions, while the electron-deficient core facilitates nucleophilic substitution. This bench-stable, moisture-tolerant reagent integrates efficiently into complex molecular architectures.

Application

2,5-Difluoropyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling site-selective functionalization via cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity profile, enhanced by the electron-withdrawing effect of fluorine atoms, facilitates efficient C–H activation and late-stage diversification. Bench-stable and compatible with standard reaction conditions, it functions as a key scaffold for heterocyclic API development and catalyst design.

General Information

CAS No. 84476-99-3
Cat. No. CS-W003160
Purity ≥97%
MDL No. MFCD04114191
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃F₂N
Molecular Weight 115.08
Synonym(s) Pyridine, 2,5-difluoro-; 2,5-Difluoropyridine
SMILES FC1=CN=C(F)C=C1

Computational Chemistry Data

TPSA 12.89
LogP 1.3598
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P302+P352

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,5-Difluoropyridine

CAS No. 84476-99-3

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