2-Chloro-5-fluoropyridine

Name: 2-Chloro-5-fluoropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 31301-51-6
Cat. No. CS-W009123
Purity≥98%
MDL No.MFCD03095332

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 31301-51-6

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Description

2-Chloro-5-fluoropyridine is a heterocyclic building block featuring complementary halogen substituents that enable selective cross-coupling reactions. The electron-deficient pyridine core supports palladium-catalyzed transformations, while the ortho-chloro and meta-fluoro groups offer distinct reactivity profiles for sequential functionalization. This molecule integrates readily into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

2-Chloro-5-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chloro and fluoro substituents facilitate sequential functionalization, while the pyridine core provides a stable, electron-deficient platform for heterocycle synthesis. Bench-stable and compatible with standard purification methods, it supports efficient access to complex scaffolds in API development.

General Information

CAS No. 31301-51-6
Cat. No. CS-W009123
Purity ≥98%
MDL No. MFCD03095332
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClFN
Molecular Weight None
Synonym(s) Benzoic acid, 2-amino-3-(trifluoromethyl)-
SMILES FC1=CN=C(Cl)C=C1

Computational Chemistry Data

TPSA 12.89
LogP 1.8741
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS05,GHS07
Signal Word : Danger	UN#: 1325
Class : 4.1	Packing Group : Ⅲ
Hazard Statements : H226-H302-H315-H318-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-fluoropyridine

CAS No. 31301-51-6

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