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CS-W001157 4
Total: USD 88.00

3,5-Dichloro-6-ethylpyrazine-2-carboxamide

  • CAS No. 313340-08-8

  • Cat. No. CS-W000778
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,5-Dichloro-6-ethylpyrazine-2-carboxamide|CS-W000778

Structure of 313340-08-8

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Description

3,5-Dichloro-6-ethylpyrazine-2-carboxamide features a pyrazine core functionalized with chlorine substituents at positions 3 and 5, an ethyl group at 6, and a carboxamide at 2. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced metabolic stability and favorable binding interactions in target-directed synthesis.

Application

3,5-Dichloro-6-ethylpyrazine-2-carboxamide serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of pyrazine-based scaffolds through standard amide coupling and electrophilic substitution reactions. Its dichloro substituents provide orthogonal reactivity for late-stage functionalization, while the ethyl and carboxamide groups offer favorable solubility and stability under routine synthetic conditions. This compound facilitates the synthesis of bioactive molecules with enhanced metabolic profile and is well-suited for parallel library generation in drug discovery workflows.

General Information

  • CAS No. 313340-08-8
  • Cat. No. CS-W000778
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇Cl₂N₃O
  • Molecular Weight 220.06
  • Synonym(s) 3,5-Dichloro-6-ethylpyrazinecarboxamide
  • SMILES CCc1nc(C(N)=O)c(Cl)nc1Cl

Computational Chemistry Data

  • TPSA   68.87
  • LogP   1.4447
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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