(R)-5-Phenylpyrrolidin-2-one

Name: (R)-5-Phenylpyrrolidin-2-one
Brand: ChemScene
Availability: InStock
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CAS No. 313352-62-4
Cat. No. CS-0098324
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 313352-62-4

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Description

(R)-5-Phenylpyrrolidin-2-one is a chiral pyrrolidinone scaffold featuring a phenyl group at the 5-position, offering high stereochemical purity and structural rigidity. This configuration enables selective engagement in asymmetric synthesis, particularly as a key building block for bioactive molecules in medicinal chemistry. The compound exhibits excellent stability under standard bench conditions and integrates readily into multi-step synthetic sequences.

Application

(R)-5-Phenylpyrrolidin-2-one serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard functionalization at the C5 position. Its inherent stereochemical purity and bench stability facilitate efficient downstream transformations, including reductive amination and nucleophilic substitution, while maintaining compatibility with common protecting group strategies. Functions as a key scaffold for CNS-targeted compounds and other pharmacologically relevant architectures.

General Information

CAS No. 313352-62-4
Cat. No. CS-0098324
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁NO
Molecular Weight 161.20
Synonym(s) (5R)-5-phenyl-2-Pyrrolidinone
SMILES O=C1N[C@@H](C2=CC=CC=C2)CC1

Computational Chemistry Data

TPSA 29.1
LogP 1.6377
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-5-Phenylpyrrolidin-2-one

CAS No. 313352-62-4

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