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CS-W001157 4
Total: USD 88.00

4-Chloro-2-(trifluoromethyl)phenylboronic acid

  • CAS No. 313545-41-4

  • Cat. No. CS-W013060
  • Purity≥98%
  • MDL No.MFCD04973086
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-(trifluoromethyl)phenylboronic acid|CS-W013060

Structure of 313545-41-4

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Description

4-Chloro-2-(trifluoromethyl)phenylboronic acid features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the chloro substituent enables downstream functionalization via cross-coupling. This bench-stable boronic acid integrates efficiently into Suzuki-Miyaura reactions, delivering arylated products with high fidelity under standard conditions.

Application

4-Chloro-2-(trifluoromethyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and vinyl halides. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the boronic acid functionality offers excellent bench stability and compatibility with diverse reaction conditions. Its orthogonal reactivity profile facilitates late-stage functionalization in complex molecule synthesis.

General Information

  • CAS No. 313545-41-4
  • Cat. No. CS-W013060
  • Purity ≥98%
  • MDL No. MFCD04973086
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BClF₃O₂
  • Molecular Weight 224.37
  • Synonym(s) 4-Chloro-2-(trifluoromethyl)phenyl boronic acid; 4-Chloro-2-(trifluoromethyl)phenylboronic acid
  • SMILES OB(O)C1=C(C=C(Cl)C=C1)C(F)(F)F

Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.0386
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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