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Structure of 31568-91-9
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2-Chloroquinolin-8-ol delivers a rigid, electron-deficient quinoline scaffold bearing a strategically positioned hydroxyl group. This combination enables direct functionalization at the C8 position and enhances metal coordination in catalytic systems. The chloro substituent provides a handle for cross-coupling reactions, while the phenolic OH supports hydrogen bonding and solubility modulation.
2-Chloroquinolin-8-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C-8 position via palladium-catalyzed cross-coupling reactions. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient access to quinoline-based scaffolds. The chloro substituent provides a reliable handle for further derivatization, while the phenolic hydroxyl supports hydrogen bonding interactions relevant in target binding. This compound functions effectively in the synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: