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CS-W001157 4
Total: USD 88.00

1,2,3,4-Tetrahydro-2,6-naphthyridine

  • CAS No. 31786-18-2

  • Cat. No. CS-0052758
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,2,3,4-Tetrahydro-2,6-naphthyridine|CS-0052758

Structure of 31786-18-2

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General Information

  • CAS No. 31786-18-2
  • Cat. No. CS-0052758
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂
  • Molecular Weight 134.18
  • Synonym(s) 10G 25G 100G
  • SMILES C1CC2=CN=CC=C2CN1

Description

1,2,3,4-Tetrahydro-2,6-naphthyridine features a saturated pyridine ring fused to a benzene core, delivering enhanced stability and tunable basicity. This heterocyclic scaffold integrates readily into medicinal chemistry libraries, serving as a key intermediate for bioactive molecule synthesis. Its bench-stable nature and compatibility with diverse reaction conditions enable efficient downstream functionalization.

Application

1,2,3,4-Tetrahydro-2,6-naphthyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to nitrogen-containing scaffolds via standard functionalization protocols. Its stable, bench-friendly structure exhibits favorable solubility and compatibility with common coupling reactions, facilitating downstream derivatization for drug discovery applications.

Synthesis

  • Route1

    References

    • Gruenenthal GmbH Patent: US2008/153843 A1, 2008 ; Location in patent: Page/Page column 57 ;
  • Route2
    • null|null
      1165952-92-0
    • ~42%
    • In-stock
      1,2,3,4-Tetrahydro-2,6-naphthyridine|CS-0052758
      31786-18-2

    References

    • Bryant, Helen Jane; Chambers, Mark Stuart; Jones, Philip; MacLeod, Angus Murray; Maxey, Robert James Patent: US2003/125333 A1, 2003 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   0.7273
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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