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Structure of 320-47-8
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4-Nitro-2-(trifluoromethyl)benzonitrile features a trifluoromethyl group and a nitro substituent positioned ortho to the nitrile on a benzene ring, creating a highly electron-deficient aromatic core. This structure enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring strong electron-withdrawing functionality.
4-Nitro-2-(trifluoromethyl)benzonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of functionalized aromatic scaffolds. Its orthogonal reactivity—combining a nitro group for reduction or displacement, a trifluoromethyl group for enhanced lipophilicity and metabolic stability, and a nitrile for downstream transformations—facilitates rapid diversification. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, simplifying purification and scale-up in synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352
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Lot numbers can be found on the outside label of a product: