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CS-W001157 4
Total: USD 88.00

4-Phenoxypiperidine

  • CAS No. 3202-33-3

  • Cat. No. CS-0156070
  • Molecule weight177.24
  • Purity≥97%
  • MDL No.MFCD04114971

*For research and further manufacturing use only, not for direct human use.

4-Phenoxypiperidine|CS-0156070

Structure of 3202-33-3

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General Information

  • CAS No. 3202-33-3
  • Cat. No. CS-0156070
  • Purity ≥97%
  • MDL No. MFCD04114971
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO
  • Molecular Weight 177.24
  • Synonym(s) None
  • SMILES C1=CC=C(C=C1)OC2CCNCC2

Description

4-Phenoxypiperidine is a versatile heterocyclic scaffold featuring a phenoxyl group tethered to the piperidine ring, enhancing its lipophilicity and metabolic stability. This structural motif serves as a key pharmacophore in CNS-targeted therapeutics, where it facilitates membrane penetration and target engagement. The compound exhibits favorable handling characteristics under standard bench conditions and integrates readily into medicinal chemistry optimization campaigns.

Application

4-Phenoxypiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization at the piperidine nitrogen and phenyl ring. Its stability under routine synthetic conditions facilitates straightforward derivatization, while the ether linkage provides metabolic resilience. The molecule functions effectively in ligand design for CNS-targeted compounds and supports diverse coupling reactions, offering practical utility in lead optimization workflows.

Synthesis

  • Route1
    • In-stock
      4-Phenoxypyridine|CS-W017655
      4783-86-2
    • null|null
      100-39-0
    • ~%
    • In-stock
      4-Phenoxypiperidine|CS-0156070
      3202-33-3

    References

    • US6124323 A1, ; US 6124323 A
  • Route2
    • tert-Butyl 4-phenoxypiperidine-1-carboxylate|CS-0733357
      155989-69-8
    • ~%
    • In-stock
      4-Phenoxypiperidine|CS-0156070
      3202-33-3

    References

    • Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 47, # 13 p. 953 - 969
  • Route3
    • null|null
      5382-16-1
    • ~%
    • In-stock
      4-Phenoxypiperidine|CS-0156070
      3202-33-3

    References

    • Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 47, # 13 p. 953 - 969

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.8174
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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