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CS-W001157 4
Total: USD 88.00

2-Fluoronaphthalene

  • CAS No. 323-09-1

  • Cat. No. CS-0072742
  • Molecule weight146.16
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoronaphthalene|CS-0072742

Structure of 323-09-1

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General Information

  • CAS No. 323-09-1
  • Cat. No. CS-0072742
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇F
  • Molecular Weight 146.16
  • Synonym(s) None
  • SMILES FC1=CC2=CC=CC=C2C=C1

Description

2-Fluoronaphthalene is a bench-stable, moisture-tolerant aromatic compound featuring a fluorine atom at the 2-position of the naphthalene core. This strategic substitution imparts enhanced electron deficiency and improved metabolic stability, making it a valuable building block in pharmaceutical synthesis and materials science applications.

Application

2-Fluoronaphthalene serves as a versatile building block in synthetic organic chemistry, enabling electrophilic substitution and transition-metal-catalyzed coupling reactions. Its fluorine substituent provides enhanced metabolic stability and modulates electronic properties, making it valuable for constructing pharmaceutical and agrochemical scaffolds. The compound exhibits good bench stability, ease of handling, and compatibility with standard reaction conditions, facilitating efficient incorporation into complex molecular architectures.

Synthesis

  • Route1

    References

    • Massachusetts Institute of Technology Patent: US2011/15401 A1, 2011 ; Location in patent: Page/Page column 18 ;
  • Route2
    • null|null
      90-13-1
    • ~10%
    • In-stock
      2-Fluoronaphthalene|CS-0072742
      323-09-1
    • In-stock
      1-Fluoronaphthalene|CS-0001469
      321-38-0

    References

    • US2010/16607 A1, ; Page/Page column 6 ;
  • Route3
    • 6-Fluoro-1-naphthoic acid|CS-W006582
      575-08-6
    • ~80%
    • In-stock
      2-Fluoronaphthalene|CS-0072742
      323-09-1

    References

    • Kruelle, Thomas M.; Barba, Oscar; Davis, Susan H.; Dawson, Graham; Procter, Martin J.; Staroske, Thomas; Thomas, Gerard H. Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1537 - 1540

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.9789
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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