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CS-W001157 4
Total: USD 88.00

4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride

  • CAS No. 32333-53-2

  • Cat. No. CS-W002150
  • Purity≥97%
  • MDL No.MFCD00024882

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride|CS-W002150

Structure of 32333-53-2

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General Information

  • CAS No. 32333-53-2
  • Cat. No. CS-W002150
  • Purity ≥97%
  • MDL No. MFCD00024882
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃Cl₂F₃O₂S
  • Molecular Weight 279.06
  • Synonym(s) 4-Chloro-3-trifluoromethyl-benzenesulfonyl chloride
  • SMILES ClC1=C(C(F)(F)F)C=C(S(Cl)(=O)=O)C=C1

Description

4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride is a highly reactive sulfonyl chloride featuring a chlorine and trifluoromethyl group in ortho substitution relative to the sulfonyl moiety. This electronic configuration enhances electrophilicity, enabling efficient coupling with nucleophiles such as amines and alcohols under mild conditions. The molecule exhibits excellent stability during storage and handling, making it ideal for use in pharmaceutical intermediates and specialty materials synthesis.

Application

4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride serves as a highly effective sulfonylating agent for the synthesis of sulfonamide derivatives. Its reactivity is enhanced by the electron-withdrawing trifluoromethyl and chloro substituents, enabling efficient coupling with amines under mild conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H290-H314
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   3.2863
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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