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Structure of 32333-53-2
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4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride is a highly reactive sulfonyl chloride featuring a chlorine and trifluoromethyl group in ortho substitution relative to the sulfonyl moiety. This electronic configuration enhances electrophilicity, enabling efficient coupling with nucleophiles such as amines and alcohols under mild conditions. The molecule exhibits excellent stability during storage and handling, making it ideal for use in pharmaceutical intermediates and specialty materials synthesis.
4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride serves as a highly effective sulfonylating agent for the synthesis of sulfonamide derivatives. Its reactivity is enhanced by the electron-withdrawing trifluoromethyl and chloro substituents, enabling efficient coupling with amines under mild conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H290-H314
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Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501
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Lot numbers can be found on the outside label of a product: