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Structure of 325-13-3
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6-(Trifluoromethyl)quinoline is a fluorinated heterocyclic compound featuring a trifluoromethyl group at the 6-position of the quinoline scaffold. This electron-deficient aryl moiety enhances binding affinity in medicinal chemistry applications and improves metabolic stability. The molecule exhibits excellent solubility in organic solvents and maintains bench-stable integrity under standard handling conditions. It serves as a key building block for kinase inhibitors, ligands in catalysis, and advanced materials.
6-(Trifluoromethyl)quinoline serves as a valuable building block in medicinal chemistry and catalytic synthesis, offering enhanced metabolic stability and lipophilicity due to the electron-withdrawing trifluoromethyl group. It functions as a versatile scaffold for palladium-catalyzed cross-coupling reactions, enabling efficient C–H functionalization and late-stage diversification. The compound exhibits good bench stability and compatibility with standard reaction conditions, facilitating its use in the development of bioactive heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: