(4-Amino-2-methyl-phenyl)-carbamic acid tert-butyl ester

Name: (4-Amino-2-methyl-phenyl)-carbamic acid tert-butyl ester
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CAS No. 325953-40-0
Cat. No. CS-0341352
Purity≥98%
MDL No.None

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(4-Amino-2-methyl-phenyl)-carbamic acid tert-butyl ester|CS-0341352

Structure of 325953-40-0

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General Information

CAS No. 325953-40-0
Cat. No. CS-0341352
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₈N₂O₂
Molecular Weight 222.28
Synonym(s) tert-Butyl (4-amino-2-methylphenyl)carbamate
SMILES CC1=CC(=CC=C1NC(=O)OC(C)(C)C)N

Description

This tert-butyl carbamate derivative features a para-amino-substituted aryl scaffold with a methyl group at the ortho position, enabling direct incorporation into peptide-like architectures. The protected amine facilitates downstream deprotection under mild acidic conditions, while the electron-donating amino and methyl groups enhance reactivity in coupling processes.

Application

(4-Amino-2-methyl-phenyl)-carbamic acid tert-butyl ester serves as a stable, bench-ready building block for the synthesis of substituted anilines and heterocyclic scaffolds. The tert-butyl carbamate group enables selective protection of primary amines during multi-step sequences, offering excellent functional group tolerance and straightforward deprotection under mild acidic conditions. It facilitates efficient coupling reactions and is well-suited for applications in medicinal chemistry and API intermediate development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 64.35
LogP 2.92422
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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(4-Amino-2-methyl-phenyl)-carbamic acid tert-butyl ester

CAS No. 325953-40-0

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