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Structure of 327-74-2
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4-Amino-3-trifluoromethylbenzonitrile features a trifluoromethyl group that enhances metabolic stability and lipophilicity, while the para-amino and ortho-cyano functionalities enable direct coupling in cross-coupling reactions. This electron-deficient aryl scaffold integrates efficiently into pharmaceutical intermediates and functional materials under standard conditions.
4-Amino-3-trifluoromethylbenzonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted benzimidazoles and heterocyclic scaffolds via cyclization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the amino and nitrile functionalities offer orthogonal reactivity for coupling and functionalization. The compound exhibits good bench stability and is amenable to standard purification techniques, facilitating integration into multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331-H315-H319
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: