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Structure of 328-80-3
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This trifluoromethyl-substituted benzoic acid features a nitro group at the meta position, delivering enhanced electron-withdrawing character. The combination of strong inductive effects from the trifluoromethyl and nitro groups imparts high acidity and stability under standard conditions. This compound serves as a key building block in medicinal chemistry and materials science, enabling efficient incorporation into bioactive scaffolds and functional polymers.
3-Nitro-5-(trifluoromethyl)benzoic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling direct incorporation of electron-withdrawing nitro and trifluoromethyl groups into aromatic scaffolds. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient derivatization, while the carboxylic acid group provides a handle for amide formation, esterification, or salt preparation in late-stage functionalization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: