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CS-W001157 4
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3-Chloro-5-fluorobenzeneboronic acid

  • CAS No. 328956-61-2

  • Cat. No. CS-W003356
  • Purity≥97%
  • MDL No.MFCD06801741

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-fluorobenzeneboronic acid|CS-W003356

Structure of 328956-61-2

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General Information

  • CAS No. 328956-61-2
  • Cat. No. CS-W003356
  • Purity ≥97%
  • MDL No. MFCD06801741
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BClFO₂
  • Molecular Weight 174.37
  • Synonym(s) 3-Chloro-5-fluorophenylboronicacid
  • SMILES Fc1cc(Cl)cc(c1)B(O)O

Description

3-Chloro-5-fluorobenzeneboronic acid features a boronate moiety flanked by chlorine and fluorine substituents, enabling efficient coupling in Suzuki-Miyaura reactions. This electron-deficient arylboronic acid offers enhanced stability and compatibility with diverse reaction conditions, delivering precise functionalization in complex molecule synthesis.

Application

3-Chloro-5-fluorobenzeneboronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. Its orthogonal reactivity profile—retaining both chloro and fluoro substituents—facilitates sequential functionalization in complex molecule synthesis. The boronic acid moiety offers excellent bench stability, ease of handling, and compatibility with diverse reaction matrices, making it ideal for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.1589
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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