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Structure of 331-26-0
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2-Chloro-5-(trifluoromethoxy)aniline features a trifluoromethoxy group that imparts enhanced electron-withdrawal and metabolic stability, while the chloro substituent enables direct electrophilic substitution. This combination delivers high reactivity in coupling reactions and facilitates access to complex heterocyclic architectures under standard conditions.
2-Chloro-5-(trifluoromethoxy)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of both electron-withdrawing chlorine and trifluoromethoxy groups into heterocyclic scaffolds. Its stability under standard reaction conditions facilitates coupling reactions, electrophilic substitutions, and amide formation with predictable regioselectivity. The molecule functions effectively in Suzuki-Miyaura and Ullmann-type transformations, offering reliable access to fluorinated aromatic systems used in pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: